Abraham dies. God prophecies the older of Isaac's twins will serve the younger. This comes to pass partly through Esau's sinfulness in despising his birthright.
How is this about Jesus?
Jesus is the younger brother in Israel (John 8) who is chosen over His older brothers, the scribes and Sadducees.
Sins this passage may reveal:
Dishonoring a spiritual inheritance (or squandering a financial one) from your ancestors by pursuit of pleasure.
Exploiting the extreme but temporary needs of others by extorting a great price from them (what Jacob does to Esau).